دراسة مناعية كيميانسيجية تراجعية لتعبيرية البروتين MDM2 في بعض أورام الغدد اللعابية

Abstract

Abstract

Background: tumors play a great influence on human life for that it must be investigated and diagnosed early, "to be able to avoid them and have appropriate treatment to it, giving the patient good chances of cure and survival

Target: Our study aimed to describe the change in the expression of the immune protein MDM2 in tumors of the salivary glands

Materials research: Pathology laboratory reports of patients suffering from salivary gland tumors retrieved from oral pathology lab in three hospitals: the oral and Maxillofacial surgery Hospital at the Faculty of Dentistry of Damascus University, the Ibn Al-Nafees Hospital and the Al-Mujtahid Hospital in Damascus during the period (2013-2017) were studied .

The sample included (24) glandular benign tumors and (26) glandular malignant tumors.

Results: positive expression of MDM2 in samples of benign tumors had an average of (32.9%), while the positive expression of MDM2 in samples of malignant tumors was (64.6%).

Conclusion: our data indicates the difference in MDM2 protein expression between benign tumors of the salivary glands and malignant tumors of the salivary glands.

Keywords: salivary gland tumors, MDM2 protein, P53 protein.