Effect of Combined Glucosamine Sulfate and Chondroitin Sulfate Application on Acceleration and Improve the Functional Treatment Efficacy of Skeletal Class II Malocclusion(A Randomized Controlled Trial)

Abstract

Objective: This study aimed to evaluate the effect of glucosamine sulfate in combination with chondroitin sulfate on acceleration and improve the effectiveness of the functional treatment of skeletal class II malocclusions.

Materials and methods: 36 patients aged between 10 and 13 years, had a skeletal class II (ANB between 4 and 8) and needed treatment with a functional removable device. The patients were randomly distributed into two equal groups. The Twin Block device with glucosamine sulfate gel and chondroitin sulfate gel was applied in the study group (18) patients, while the Twin Block device with placebo cream was applied in the control group (18) patients. Diagnostic records were taken, then functional devices were applied, and patients were asked to take a cephalometric radiograph before and after treatment. The Viewbox program was used to study the cephalometric images and extract the results. Mann-Whitney test and independent samples t-test were used to study the changes in the mean differences in the period of functional treatment and the changes in the values ​​of linear measurements and angles between the two study groups. Wilcoxon's test and paired t-test were used to study the changes in the values ​​of linear measurements and angles within each group.

Results: There were no statistically significant differences when comparing the period of functional treatment between the two study groups (p = 0.705). It was found no significant differences when comparing the angles and linear measurements between the two study groups (p > 0.05). While, there were significant differences when comparing all angles and linear measurements before and after treatment within each group except for angles (NSL ˄ NL), (NSL ˄ ML), (Ar-Go-Me), and (NL˄ ML) in addition to the Bjork sum ratio Jarabak (p>0.05).

Conclusions: The application of glucosamine sulfate in combination with chondroitin sulfate may not have an effect on the period of functional treatment and the angles and linear variables on cephalometric images.Keywords: Structural Class II, Glucosamine Sulfate, Chondroitin Sulfate, Twin Block, Functional Therapy