Formulation and in-vitro Evaluation of Orally Disintegrating Tablet of Furosemide Prepared by direct compression.

Abstract

Furosemide is a loop diuretic widely used in the treatment of edema associated with congestive heart failure, pulmonary edema and other cardiac diseases. There are several commercial forms of furosemide, including tablets, injections and oral syrups. This research aims to formulate furosemide in the form of Oral Disintegrating Tablets (ODT) for patients who have difficulty swallowing or to increase the speed of the effect compared to normal tablets or to overcome the unpleasant taste of the syrups. Several formulations of oral dispersible furosemide tablets have been prepared in which two types of super disintegrants Croscarmellose Sodium, Sodium Starch Glycolate (Primojel) and in different percentage were used.

Physical examinations were performed on the resulting formulations and a dissolution test was applied, which showed the release of a large amount of the active pharmaceutical ingredient in the first minute. The results showed that the formula containing 3% Croscarmellose Sodium gave the best release of the Furosemide in the dissolution test, which will be reflected in the bioavailability and on the pharmacological effect of furosemide.

Keywords: Oral Disintegrating Tablets, Furosemide, Dissolution Test.