comparative study of glucose rich and glucose free diet in oral squamous cell carcinoma induced in hamsters

Abstract

Introduction: Oral cancer is common neoplasia worldwide, of which nearly 90% are diagnosed as oral squamous cell carcinoma (OSCC), Tumor metabolism is an essential contributor to disease progression and response to treatment.

Aim of the research: Studying the effect of a diet (glucose-rich) or (glucose-free) on the stages of histological development of squamous cell carcinoma induced in hamsters, and compare them.

Materials and Methods: 40 of the experiment’s Syrian Hamsters were incubated in tow groups: 1st one consisted of 20 hamsters (group on which the carcinogenic material was applied within the cheek pocket three days per week with a diet glucose-rich) ، while the 2nd one was 20 hamsters (group which the carcinogenic material was applied within the cheek pocket three days per week with a diet glucose-free), Hamsters in both groups were sacrificed to groups of 5 hamsters at a time and at intervals (5 after 2 weeks, 5 after 6 weeks, 5 after 10 weeks and 5 after 14 weeks). Histological study was performed after conventional staining with hematoxylin and eosin

Results: There are no statistically significant differences between a glucose-rich diet and a glucose-free diet.

Conclusion: It cannot be starved oral squamous cell carcinoma by cutting sugar as it finds alternatives to gluconeogenesis.