The protective effect of Vitamin A on Vancomycin-induced Nephrotoxicity in Rat

Abstract

Aim: Vancomycin (VAN) is a glycopeptide antibiotic which is active against gram positive bacteria including methicillin resistant Staphylococci. Free radicals are involved in the pathogenesis of vancomycin-induced nephrotoxicity. Therefore, the present study was conducted to investigate the antioxidant potential of Vitamin A against the nephrotoxicity of vancomycin in rats.

Methods: Animals used in this study were divided into; Control, VAN treated, VAN + vitamin A treated group. vitamin A (4000 IU/Kg) was administered 4 days before and 2 weeks simultaneously with vancomycin (300 mg/kg). Serum separated to determine kidney function parameters. Kidneys dissected out for histological examination and for assay of oxidative stress markers.

Results: Lipid Peroxidation (MDA) in kidney tissue were significantly increased after vancomycin administration. VAN produced kidney dysfunctions. The presence of Vitamin A with vancomycin caused reduction in induction levels of MDA, urea and creatinine in kidney.

Conclusions: Vitamin A has beneficial influences and could be able to antagonize vancomycin nephrotoxicity.