Using Platelet Rich Plasma for the Management of Peripheral Nerves Crush Injuries

Abstract

Background & Aim: Peripheral nerve crush lesions are common injuries. although the peripheral nerve tissue has the ability to regenerate, the tissue healing may associated with complications and sequelae that prevent functional recovery, which leads to significant functional impairments. Some previous studies showed positive effects of using Platelet rich plasma (PRP) on healing process after peripheral nerve injuries.

This research aims to determine the effect of Platelet rich plasma on healing process after peripheral nerve crush injuries by using different types of Platelet rich plasma.

Materials & Method: 60 rats were used and divided into 5 groups (group1:normal group). Crush injuries were performed on the right sciatic nerves in the other groups,

(group 2 damaged) was lift without treatment and (PRP) types were applied to the injured nerve areas as follows: (group 3 PRP)  (group 4 PRF) ( group 5 LPRP).

The histological evaluation were Performed after 4 weeks and 8 weeks.

The results showed significant differences between (PRP&damaged)-(PRF&damaged) - ( LPRP & damaged) in the first phase, and showed significant differences between (PRP&damaged) - (PRF&damaged) in the second phase. When comparing between treatment groups the results showed no significant differences in the first phase, while in the second phase there were significant differences between (PRF&LPRP) for axons daimeters, and between (PRF&LPRP)-( PRP-LPRP) for myelin sheath thickness.     

Conclusion: The results of this research suggest that this different types of  PRP improves the tissue healing process in the early stages after peripheral nerve crush injuries, and the results also showed a specific effects of  (PRP-PRF) types in the later stages of healing process.