Amniotic Membrane Transplantation as a Treatment for Persistent Corneal Defects

Abstract

The use of اhuman amniotic membrane (HAM) has been suggested to manage various ocular surface diseases for its effective properties. The aim of this study was to investigate the effect of dried AmniGraft as Syrian product transplantation (DAG-SY-T) for Non-healing, persistent epithelial defects (NH-PED). The study included 3 patients that were assigned to DAG-SY-T  in Damascus Eye Surgical Hospital, The patients underwent a comprehensive ocular examination, visual acuity, epithelial defect; The main outcome measures were healing response of PED after longstanding ocular surgeries, and time to heal after application of DAG-SY-T. Visual acuity improved significantly in all patients after DAG-SY-T treatment. One week later the defect was reduced. During the 3 months follow-up, no recurrence was observed. DAG-SY-T can be easily applied in the clinical setting and has demonstrated its efficiency as a new tool to treat PEDs after longstanding ocular surgeries.