Study of the antifungal activity of Citrus sinensis oil against Candida sp. Causing a group of infections and corresponding side effects in the physiology of the digestive system (Clinical – Laboratory study)

Abstract

Abstract:

Introduction: Based on the large spread of bacterial strains that are resistant to antibiotic treatment, and fungal strains are added to them today, especially Candida, which is resistant to a wide spectrum of antifungals, it was necessary to go to a preliminary study that contributes to the search for new alternatives proposed in the future as antifungals against the most dangerous causes of fungal infection in the world (Candida), including This study aimed to test the effectiveness of Citrus sinensis peel oil against the Candida species that cause a group of different infections and the corresponding side effects at t//he same time on the health of the digestive system.

Materials and methods: Samples were collected from the Children's University Hospital \ Damascus, laboratories for bacterial diagnosis. Laboratory cultures diagnosed with fungal infection (candida) were relied upon. The fungal diagnosis of candida was confirmed in the laboratory (laboratories of the College of Dentistry \ Department of Basic Sciences) by following a set of cultures and biological interactions. And then study the effectiveness of Citrus sinensis peel oil against Candida on solid media compared with a group of known resistant bacteria, in the last stage the application of Citrus sinensis peel oil extract as an emulsion on the small intestine isolated from the rabbit to study the side effects on the digestive system.

Results: Citrus sinensis oil has antifungal and antibacterial activity against Candida fungi and a group of Gram-negative and Gram-positive bacteria, with known resistance. It is noted that its effectiveness against germs is stronger than its effectiveness against fungi. At the same time, Citrus sinensis peel oil leaves an inhibitory effect on the movement of the small intestine, with low concentrations of it.

Conclusions: Citrus sinensis oil is one of the natural source substances that have antibacterial and fungal activity against a wide spectrum of fungi and germs. one article.