Studying the α-glucosidase inhibition activity of Tribulus terrestris L. leaves and fruits extracts

Authors

  • Kh. Alkhaldi, Dr. Th. Al_Haddad, Dr. M. Daghestani

Keywords:

: Tribulus terrestris L., antidiabetic activity, α-glucosidase enzyme.

Abstract

Tribulus terrestris L. leaves and fruits were extracted by means of ultrasonication using solvents of increasing polarity: hexane, acetone, ethanol, and water. The in vitro anti-diabetic activity of different concentrations of these extracts was evaluated by studying their inhibition activity against α-glucosidase enzyme, in addition to study the inhibition mode for the most effective extract. All extracts showed varying inhibition activity against α-glucosidase, The higher inhibition activity was observed in the non-polar or low polar extracts (hexane and acetone). The hexane extract of fruits had the highest inhibition activity IC50=27.28μg/ml, and the inhibition mode was noncompetitive.

 

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Published

2021-08-08

How to Cite

Studying the α-glucosidase inhibition activity of Tribulus terrestris L. leaves and fruits extracts. (2021). Damascus University Journal for the Basic Sciences, 37(1). https://journal.damascusuniversity.edu.sy/index.php/basj/article/view/859