Prognostic and Therapeutic Significance of Marker CD105 in Invasive Breast Carcinoma

Abstract

Background & Aim: Studies showed that even if a solid tumor possesses all of the genetic aberrations that are required for malignant transformation, it cannot enlarge beyond 1 to 2 mm in diameter unless it has the capacity to induce angiogenesis Angiogenesis is a complex multistep process required for tumor growth and metastasis. It involves endothelial cell migration and proliferation, microvessel differentiation and anastomosis, and extracellular matrix remodeling.

We aimed to determine the prognostic value of marker CD105 in invasive breast carcinomas, its correlation with  risk  of lymph node metastasis and other clinicopathological factors such as: tumor size, grade, histologic type ,lymph node status, No of involved lymph nodes and  percentage of KI67.

Materials and methods: evaluation of  intratumoral microvessel density by using CD105 marker expression in tumor sections of  patients with breast carcinoma in Al_Assad University Hospital. Spearman's rho correlation was used to test the correlation between the immunohistochemical findings , conventional clinicopathological features and expression of markers. Statistics software (SPSS, version 10.0; SPSS, Inc., Chicago, IL, USA) was used for all calculations.

Results:The count of CD105+microvessels proved to be valuable prognostic indicator which exhibited a predictive value stronger than tumor grade, histological type even in node negative patients.

No correlation was found between CD10 over expression and age,Tumour grade and histological type. 

Conclusion: CD105 detection may be useful not only in terms of prognostic significance, but also in the potential selection of candidates who could benefit from specific antiangiogenic therapy with anti-CD105 antibodies