Risk of Placental Dysfunctional Disorders after Prior Miscarriages

Abstract

- Objective: The research aims to study the relationship between miscarriages history and the risk of placental dysfunction disorders including preeclampsia, stillbirth, Small for gestational age (SGA), intrauterine growth restriction (IUGR), placental abruption, and spontaneous preterm birth.

- Materials and Methods: A Prospective Cross-Sectional Study, conducted in the Obstetrics and Gynecology University Hospital at Damascus from 29/7/2020 to 29/7/2021, included 800 primiparous women (400 haven't a prior miscarriages, 308 have a one prior miscarriages, 57 have two prior miscarriages, 35 have three or more prior miscarriages).

- Results: Compared with women with no prior miscarriage, women with 1, 2, 3 or more prior miscarriage had an increased Odds ratios of each of gestational diabetes (OR 1.1, 1.2, 1.5, respectively) and gestational hypertension (OR 1.1, 1.5, 2.1, respectively), preeclampsia / eclampsia (OR 1.2, 1.6, 2.1, respectively), preterm placental abruption (OR 1.7, 3.1, 3.4 respectively) , term placental abruption (OR 1.6, 1.4, 3.7, respectively), spontaneous preterm birth (OR 1.5, 1.8, 2.3, respectively), cesarean delivery (OR 1.2, 1.8, 4, respectively), IUGR (OR 1.8, 2.4, 2.6, respectively), SGA (OR 1.6, 1.7, 2.9, respectively), and stillbirth (OR 1.8, 3.3, 5.6, respectively). There was a statistically significant relationship between the increase in the number of prior miscarriage and each of the increased pregnant woman age, cesarean delivery, decreased mean fetal / newborn weight, the stillbirth and the newborn's need an incubator.

- Conclusions: History of one or more prior miscarriage is associated with an increased risk of placental dysfunction disorders and should be regarded as a risk factor in antenatal care.