Oral Malignant Melanoma: A Review of the Literature and case report of Hard Palate Malignant Melanoma

Abstract

Oral malignant melanoma (OMM) is a rare malignant lesion of the oral mucosa. Most cases arise on the palate or gingiva. We made A Review of the Literature focused on relevant molecular and clinical advancements for the oral melanoma to describe the updated knowledge relating to main diagnostic, clinical, and therapeutic implications .And report a case of malignant melanoma of the hard palate extending to the buccal gingiva in 59-year-old Female patient, Final diagnosis was done based on clinical features and H&E and immunohistochemistry (for human melanoma black (HMB)-45 and S-100 protein)for incisional biopsy.  Maxillectomy and bilateral neck lymph nodes curettage was done, after surgery radiotherapy was administered 38.4 Gray (32 doses – 1.2 Rad per dose -twice a week) over a period of 3 months and supportive immunotherapy was done also and there were no signs or symptoms to any recurrence after 12 months follow up period.

Careful clinical examination of patients with unusual focal pigmented lesions in the oral cavity and early detection by histopathological means of pigmented growth and periodic follow-up of patients are essential for a better prognosis of this lethal entity.