Effect of Different Types of Platelet Rich Plasma on Peripheral Nerve Injurie

Abstract

Abstract

Background & Aim: In recent years the platelet rich plasma  therapy (PRP) appears as one of biological treatments for stimulating  tissue healing, depending on the biological effects of substances secreted by activated platelets .several studies showed improvement in nerve regeneration using platelet rich plasma therapy after peripheral nerve injuries. But the results remains controversial because researchers  used  different types of PRP

This study aims to compare the effects of different types of PRP on nerve regeneration in traumatic peripheral nerve

Materials & Methods: Sixty rats were used and divided into five groups  (control group 1). Crush  injury was performed on the sciatic nerves in the other groups , and  PRP were applied to the injury nerve area as follows:

(group 3 PRP) (group 4 PRF) (group 5 LPRP), and (group 2 damaged) was lift without treatment. The electrophysiological  evaluation were Performed after 4 weeks and 8 weeks.

The results showed significant differences between  (PRP & DAMAGED) and between ( PRF & DAMAGED) and no significant difference was observed between  (LPRP & DAMAGED), comparing the treatment groups shows no significant difference between ( PRP & PRF), but there were significant differences between ( PRP-LPRP) and between ( PRF-LPRP).

Conclusion: PRP and PRF therapy improve nerve regeneration after traumatic injury in peripheral nerve, while LPRP had no specific affect.