Investigating of efficacy of Troxerutin and Alpha Lipoic Acid in induced depression in mice

Abstract

Background & Aim:  Depression is a common psychiatric illness that has been established to be associated with a decrease in serotonin and/or serotonin transporters in the brain. Multi studies show that Inflammation can cause depression. Traditional treatments such as psychotherapy are time consuming and very expensive and antidepressant medications carry potential risks such as palpitations, sexual dysfunction and seizures. Troxerutin is a naturally occurring compound that has various favorable biological activities such as antioxidant, anti-inflammatory, anti-diabetic and anti-tumor. The antioxidant alpha lipoic acid has been shown to increase insulin sensitivity that incease serotonine activity in brain.

Materials and Methods: 30 mice were randomly devided into different five groups (n= 6), group 1: control group was not given any drug, group 2: imipramine group (IMIP) was given drug orally (60 mg/kg), group 3: Troxerutin group (TROX) was given drug orally (150 mg/kg), group 4: compination group (IMIP + TROX), and group 5: Alpha Lipoic Acid group (ALA) was given drug orally (150 mg/kg). Tail Suspenssion Test, Forced Swimming Test, and Sucrose Preferance Test were done.

Results: Treatment with TROXE (150 mg/kg) and ALA (150 mg/kg) attenuated the depressive-like behavior in treated mice.

Conclusion: Antioxidants could serve as an alternative therapeutic tool for the treatment of depressive disorders