Bacteria isolated in Pneumonia in children with Cystic Fibrosis and its antibiotic sensitivity

Abstract

Abstract

Background & aim : Cystic fibrosis (CF) is an autosomal recessive multisystem disease that affects the lungs, digestive system, sweat glands, and the reproductive tract. It is characterized by chronic obstruction and life-threatening infections in the respiratory tract.

Studying the most common isolated pathogens from respiratory infections in cystic fibrosis patients using oropharyngeal swab (OP) or bronchoalveolar lavage (BAL) and its antibiotic sensitivity. Studying the pathogens’ relationship to age, previous hospitalization, and mortality.

Methodology: This is a retrospective cohort study of 26 children with cystic fibrosis that admitted to Damascus Children University Hospital with a respiratory tract infection between 2014-2019. We access patients’ files and collected necessary information.

Findings: %53.8 cases were males and %46.2 were females. Most patients were infants (%61.5). We isolated 10 pathogens which are: P. aeruginosa, Acinetobacter, S. aureus, Fungi, K. pneumonia, Enterobacter, S. pneumonia, Normal Flora, E.Coli, and Enterococcus sorted by the most common. Enterococcus, Normal Flora and S. aureus was the most common in infants, while P. aeruginosa and Acinetobacter increased after year 1 and the existence of previous hospitalizations. We also noted its relationship to increased mortality.

 Studying the antibiotic sensitivity, we notice that most pathogens are susceptible to Colistine, Amikacin, Tazocine (Piperacillin-Tazobactam), and Gentamycin because Gram-negative bacteria were the most pathogens we found. While there was little susceptibility to Cefotaxime and Augmentin.

Conclusion: We notice the dominance of Gram-negative bacteria, especially P. aeruginosa, in respiratory infections in children with cystic fibrosis, and its colonization

in the respiratory tract with the chronic disease, recurrence, and antibiotic-resistance.