Effect of some prognostic factors on overall survival in patients with colorectal carcinoma

Abstract

Background: Colon adenocarcinoma is the most frequently encountered cancer of the gastrointestinal tract. The prognosis of colorectal carcinoma (CRC) patients varies greatly between patients with 5-year survival rates ranging from 90% to 10% depending on stage and other factors. The Prognostic of colorectal carcinoma  relies mainly on cancer stage as defined  by the TNM staging classification. There are considerable differences in clinical outcomes and prognosis within patients of the same pathological stage, especially within the intermediate stages of CRC (stages II and III)

Material  and  Methods: This study (retrospective study) was designed to

evaluate the prognostic impact of a wide spectrum of  pathologic parameters on overall survival in patients with colorectal carcinoma.

Results: Histological grade of tumor, presence of  lymphovascular invasion, depth  of tumor  invasion and  number of metastatic lymph nodes were found to be independent prognostic factors for  the overall survival.

Conclusion: Understanding the pathological features of each tumor and  how  they  impact  treatment  and survival may lead to more specific prognostication  and  treatment  protocols.