Effects of Naproxen and Celecoxib Administration on Postoperative Pain After Single Visit Root Canal Treatment

Abstract

Aim: The aim of this study was to evaluate the efficacy of celecoxib compared to naproxen in the management of post-endodontic pain in single-canal anterior and premolar teeth with irreversible pulpitis.

Methods: Sixty single-canal anterior and premolar teeth with irreversible pulpitis were included in this study. Patients were randomly allocated into three groups according to the administered medicament: naproxen group (n=20), celecoxib group (n=20), and placebo group (n=20). Naproxen group received naproxen 500 mg tablets, celecoxib group received celecoxib 100 mg capsules, and placebo group received placebo (starch containing capsules). All patients were given one tablet/capsule at the following time intervals: 1 hour preoperatively, 12, 24, 36, 48, hours postoperatively. A single operator performed a single-visit endodontic treatment for all patients. Visual analogue scale (VAS) was used to record pain at 6, 12, 24, 48 hours and 1 week after obturation. Data were statistically analyzed using Kruskal-Wallis and Mann-Whitney U tests. The significance level was set at p<0.05.

Results: There were no statistically significant differences in VAS pain values between the studied groups 6, 12, 48 hours, and 1 week after obturation (p>0.05). At 24 hours after obturation, there were no statistically significant differences between naproxen and celecoxib groups (p>0.05). However, there were statistically significant differences between placebo group and both naproxen and celecoxib groups at that time (p<0.05).

Conclusions: Naproxen and celecoxib were found to be effective in reducing post-endodontic pain in single-canal anterior and premolar teeth with irreversible pulpitis. The effectiveness of naproxen was similar to celecoxib.