Relationship between left ventricular mass index and cardiac function in pediatric hemodialysis patients

Abstract

Objective: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in children with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) and diastolic dysfunction(LVDD)are early markers, Left ventricular mass index (LVMI) is a surrogate of left ventricular hypertrophy and a predictor of cardiac morbidity and mortality in adults with hypertension.

The aim of this study was to identify an association between elevated LVMI and echocardiographic markers of systolic and diastolic function.n

Materials and Methods: This prospective study included 23 children of chronic dialysis patients who are  between 4-14 years from 2020-2021 , we excluded congenital heart diseases, and renal insufficiency following neoplastic injury, We performed echocardiography for all patients included in the study, we collected information (echo result, age, weight, sex), put them in schedules and made data analysis. We compare the results with previous studies.

Results: Left ventricular hypertrophy was present in 22 patients (95.6 %). and the most common cardiac geometry was concentric LV hypertrophy (65.2%).

Diastolic function evaluated with TDI (E/E=`early/late diastolic myocardial velocity) worsened with increased of Left ventricular mass index (LVMI).(P value = 0.009) diastolic dysfunction found in 69.3% of patient.

Conclusions:. Elevated LVMI is associated with decreased diastolic cardiac function, justifying its use as a surrogate of cardiomyopathy in children undergoing chronic dialysis Tissue Doppler  is a simple producer and more accurate diagnostic tool in early diagnosis of diastolic dysfunction.