Preparation of transdermal patch films from different mixtures of polymers using solvent casting method and their Physical evaluation

Abstract

Background & Aim: The research aims to prepare transdermal patch films from different mixtures of hydrophilic and lipophilic polymers by the solvent evaporation technique using different types of plasticizers like propylene glycol, castor oil and glycerin .Formulated transdermal patches were physically evaluated with regard to thickness, weight variation, folding endurance, percentage of moisture content and moisture uptake. Formulations (P7,P8,P9,P10,P11) consisting of ethyl cellulose(EC),polyvinyl pyrrolidone (PVP) as polymers, propylene glycol and castor oil as plasticizers were the lowest in moisture content and moisture uptake, they had regular thickness and high folding capacity. Formulations (P1,P2,P3,P4) consisting of hydroxy propyl methylcellulose(HPMC) ),polyvinyl pyrrolidone(PVP) as polymers, glycerin 5%v/v as plasticizer were semi solid films and the highest in moisture content and moisture uptake because of hygroscopic nature of polymers.