Diabetic Foot Ulcers (DFUs) healing by using dried and gamma irradiation sterilized Amniotic membrane (AmnioGraft)

Abstract

Abstract:

Human amniotic tissues have unique characteristics, properties, and some therapeutic potential for wound, burn and ulcer and other diseases healing.  Clinical analysis results conducted in national medical clines and hospitals indicated the possibility of using the AmnioGraft as domestic products for healing some diseases.  Within the series of these works implemented locally to evaluate the possibility of using the AmnioGraft as available option in treatment of non-healing diabetic Foot Ulcers (DFUs) in the burn and plastic surgery ward of Damascus hospital, by covering the damaged area of the foot by AmnioGraft, often folded three times was sutured on mean postoperative weeks 0, 1, and 3. The clinical and laboratory results indicated that, the use of AmnioGraft for non-healing healing DFUs can be considered highly effective to improve the healing of ulcers. The pain, exudation/dryness degree, weight blood cells (WBCs), and the body temperature were reduced, and the wound healing was accelerated. Based on this information the use of AmnioGraft for healing DFUs can be considered as regeneration graft. Our recommendation to estaplished surgery protocol for Diabetic Foot Ulcers (DFUs) healing by using AmnioGraft as locally products for applying it’s in the domestic hospitals.