Investigation of the Efficacy of Alpha-Lipoic Acid in the Prevention of Gastric Ulcers Induced by Ketorolac

Abstract

Abstract:

Background and Objective: Gastric ulcers are a common gastrointestinal disorder that constitutes a burden on health care systems. Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) are the main causes of ulcer disease. Oxidative stress is involved in the initiation and progression of injury. Alpha lipoic acid (ALA) is an important antioxidant and is used for the treatment and prevention of diseases associated with oxidative stress.

Research materials and methods: 17 Wistar albino rats were divided into three groups: negative control group (NC), and positive control group (KET), which was given ketorolac at a dose of 30 mg/kg orally to induce gastric ulcers after 24 hours of fasting. Alpha lipoic acid group (ALA), which was given alpha lipoic acid at a dose of 100 mg/kg orally one hour before ketorolac administration. Macroscopic and microscopic examination of stomach tissue was performed, and tissue oxidative stress parameters were examined.

Results: Ketorolac caused damage to gastric mucosa, represented by an increase in the ulcer index, infiltration of neutrophils into the stomach tissue, as well as an increase in parameters of oxidative stress. ALA was not shown to be effective in preventing ketorolac-induced damage macroscopically or microscopically, but it was able to reduce oxidative stress parameters.

Conclusion: A single dose of ALA was able to cause a decrease in the parameters of oxidative stress induced by ketorolac, but this was not reflected in the macroscopic and microscopic features.

Keywords: Gastric Ulcer, Ketorolac, Alpha-Lipoic Acid, Oxidative Stress.