دراسة العامل المشتق من الخلايا اللحمية -1 (SDF1-α) لدى المرضى المصابين بالتهابات المسالك البولية والتهاب المهبل الجرثومي

الملخص

Background: Study stromal cell-derived factor-1 is produced soon after an infection, an interesting immunological response is triggered, allowing for quick and effective bacterial clearance. Urinary tract infections and bacterial vaginosis are two major hazards that have an impact on millions of women worldwide that are of reproductive age. The purpose  of this study is to analyze the connection between the SDF1 gene in patients both urinary tract infections with bacterial vaginosis and healthy individuals as a control group.    

Methods: In order to study the distribution of the SDF1 gene the Gynecology Consultant at the Imam Al-Sadiq General Educational Hospital in Iraq-Babylon split the topics to four collections after collecting medical data from (240) entrants. the patients and the control group (UTI, BV, UTI with BV groups), while the population study in this area included age and education, During the period from September to December 2022, SDF1-α detection by Conventional amplified technique (PCR) - We reveal alleles with a single primer and distinguished the alleles by molecular weight.

Results: The results revealed that patients and a control group who have G allele, and  G/G genotyping in the SDF1-α gene, had no significance, therefore considered a protective factor to the development of disease, for urinary tract infection, particularly among women of childbearing age in college education. Also, women with bacterial vaginosis especially among women sexually active in Intermediate education, also women with both UTIs with BV especially among women sexually active studying in the institute.

Conclusion: According to our research, SDF1-α/CXCL-12 gene polymorphism is not linked to BV-associated UTIs. To further explain these findings, a larger-scale and well planned case-control research should be carried out.