the Correlation between the presence of rs7088318 for PIP4K2A polymorphism and the sex, age and immunophenotype of Syrian Patients with acute lymphoblastic leukemia

Abstract

The PIP4K2A gene encodes for a class II kinase of a family of kinases known as phosphatidyl inositol 5 phosphate 4 kinase (PIP4K), which in addition to PIP4K2A includes both PIP4K2B and PIP4K2C. PIP4K2A has the highest enzymatic activity of this family. Several studies have indicated the importance of the PIP4K2A gene as one of the risk loci that genetically predisposes to acute lymphocytic leukemia ALL, and other studies have shown that the expression of PIP4K2A is strongly affected by the genotypes of single-nucleotide polymorphisms, Thus, there is an association between the SNPs of this gene, especially rs7088318, and leukemogenesis through the induction of overexpression of the gene. At the same time, current evidence showed an association between susceptibility to ALL and the Ethnicity-Specific and Subtype-Specific leukemia gene PIP4K2A. This study aimed to identify the frequency of the rs7088318 polymorphism allele in a population of Syrian patients with acute lymphoblastic leukemia and to investigate the relationship between the genotype and the patient's sex, age and immunophenotype. Our cross-sectional descriptive study included 114 patients with ALL of both sex, children and adults of different immunotypes, whose genotype was identified by ARMS-PCR. The data were analyzed based on the statistical software SPSS released 23. The frequency of the heterozygous T allele reached 80% in the study population, and there were no statistically significant differences between the frequency of this allele and under the disease groups, which shows that there is no correlation between the rs7088318 polymorphism and each of the sex. Age, and immunophenotype of

Syrian patients with acute lymphocytic leukemia.

This study highlights the need for further investigations to identify frequencies of alleles at other genetic loci in Syrian patients with acute lymphocytic leukemia and to assess their impact on susceptibility to disease occurrence, response to chemotherapy, and prediction of relapse in patients.