Prognostic Significance of p53 Expression in Breast Carcinoma

Abstract

Background & Aim: Breast cancer is the most frequently diagnosed cancer among females worldwide. p53 tumor suppressor gene regulates the cell cycle and DNA repair and its over-expression in breast carcinoma is associated with a worse prognosis.

The aims of the our study are; first, to determine the frequency of p53 overexpression in different types of  infiltrating breast carcinoma. Second, to study the correlation between the p53 over-expression with different parameters, including the age, size, grade,  histologic  type. the status of lymph nodes, CD10 expression .Third, to compare our results with others

Methods: The study included 100 cases of breast carcinoma. Data were obtained from archives of the pathology department, at AL-Assad University Hospital in 2017 .p53 over-expression was assessed immunohistochemically. .

Results: The patients ages ranged from 33 to 79 years ,most of them were in the fifth decade (32%). There was a significant positive relation between p53 over-expression and KI67 expresssion (P=0.000), and HER2/neu (P=0.038). There was a significant direct correlation between p53 over-expression and molecular classification (p=0.000), grade (p=0.002), axillary lymph node metastasis (p=0.000) and CD10 expression(p=0.000). p53 over-expression was found in (100%) of micropapillary carcinoma , (93.3%) of invasive breast carcinoma (NST), (50%) of invasive cribriform, and (53.3%) of invasive lobular carcinoma.

Conclusions: p53 over-expression was significantly correlated with pathologic parameters refer to worse prognosis ,  so p53 overexpression was found to be poor prognostic factor and its detection may help in risk catergorization and designing future target approaches.