Study of Anti-TPO Antibodies (Thyroid Peroxidase) Frequency in Vitiligo Patients

Abstract

Abstract

Background and aim: The aim of this study was to determine the prevalence of thyroid autoimmunity diseases  in vitiligo patients.

Materials and Methods: This is a case –control study consists of 75 healthy individuals and 72 vitiligo patients.

Patients and healthy individuals with known thyroid disease on thyroid medication, those who had undergone thyroid surgery, and patients who declined to sign informed consent were excluded. Serum anti-TPO antibodies were measured.

Results: The prevalence of anti-TPO antibody positivity was found to be 19.4% in the vitiligo group. Whereas the prevalence of anti-TPO antibody positivity was found to be 6.7% in control group.

Conclusion: According to our study, none of our vitiligo patients had symptoms or signs of thyroid disease at the time of presentation , but on biochemical evaluation , anti-TPO antibodies were found in a considerable number of patients. That we recommend screening of these patients with thyroid antibodies to manage vitiligo patient with positive anti –TPO in similar way of managing Autoimmune Thyroid Diseases.