Efficacy of hyaluronic acid addition to collagen on reducing the severity of symptoms following surgical extraction of impacted lower third molars Clinical Study

Abstract

Aim of the study: This study aims to evaluate the effectiveness of adding hyaluronic acid to collagen when applied topically on the severity of symptoms following surgical extraction of the impacted lower third molars.

Materials and Methods: This randomized split-mouth controlled study included 20 patients (5 males and 15 females) with a mean age 22.7 ± 3.079 undergoing the surgical removal of bilateral impacted mandibular third molar. Group study were randomly divided to collagen (Group A), collagen and hyaluronic acid (Group B). The surgical procedure for the both side was done in separated appointments in intervals at least 2 weeks. On the postoperative seventh day, Patients  were completed the postoperative symptom severity (PoSSe) scale to comprehensively and quantitatively evaluate their quality of life after surgical tooth extraction.

 Results: The study shows that the mean numerical value of PoSSe in the collagen and hyaluronic acid group was significantly  lower than that of the collagen alone ( P-value<0.05). We found statistically significant differences for the questions related to unable to open mouth, voice affectedness, speech affectedness, Influencing daily life and Influencing free time activities.

Conclusion: Within this study limits, Adding hyaluronic acid to collagen is effective in reducing the severity of symptoms following surgical extraction of impacted lower third molars.