Evaluation of ACEIs "Lisinopril" Effect on Body Iron Storage in Rats

Abstract

Background and aim: Iron overload can have detrimental health effects. Angiotensin II is involved in body iron storage. Therefore, the current study aimed to investigate angiotensin-converting enzyme inhibitor "lisinopril" efficacy in reducing body iron content under iron overload conditions, using an experimental model induced by ferrous sulfate in rats.

Materials and methods: 23 male Albino Wistar rats, divided into three groups; control: distilled water 1ml/day, Iron overload: ferrous sulfate 30 mg/kg/day, treatment with Lisinopril: ferrous sulfate + Lisinopril 1 mg/kg/day intraperitoneal injections daily for 14 days. Body iron stores were evaluated by hepatic and serum iron assay.

Results: Ferrous sulfate increased body iron storage as evidenced by elevated serum and hepatic iron levels. Lisinopril did not cause a significant reduction in iron parameters when injected daily for 14 days (P > 0.05).

Conclusions: Angiotensin inhibition may not be beneficial in reducing body iron stores under iron overload conditions.