Evaluation of the efficacy of injectable platelet-rich fibrin in the management of oral lichen- Clinical study

Abstract

Background & Aim: The aim of this study was to evaluate the efficacy of intralesional injection of platelet-rich fibrin compared with triamcinolone acetonide in the management of oral lichen planus lesions.

Materials and Methods: This study is a randomized controlled clinical study that has a split-mouth design. The sample consisted of 12 patients (3 males and 9 females) with an age range from 24 to 65 years, Patients who presented symptomatic oral lichen lesions bilateral, symmetrical,  buccal lesions. They were randomly divided into two sides: one side received 1 ml Platelet-rich fibrin injection and 0.5 ml Triamcinolone acetonide injection in the opposite side Once a week for a month, clinical resolution and recurrence rate were evaluated and followed up for 3 months.

Results: The study showed that platelet-rich fibrin is effective in the management of oral lichen planus, and there were no significant differences in the clinical resolution index p-value = 0.33 and recurrence rate index p-value = 0.23 between the platelet-rich fibrin and triamcinolone acetonide groups.

Conclusion: Within the limits of this study, injectable platelet-rich fibrin can be considered as a promising therapy in the management of oral lichen.