Antibiotics sensitivity of Carbapenem-Resistant Enterobacteriaceae species at University Children's Hospital in Damascus

Abstract

Abstract

Background: The spread of antibiotics bacterial resistance is still a therapeutic challenge, as theses bacteria develop multiple mechanisms of resistance to current antibiotics, in this study, we focus on Carbapenem-Resistant Enterobacteriaceae species, as there are few studies conducted on these bacteria in children, in order to determine our best treatment options.

Methods and Materials: A prospective, single-center analytical cohort study of children with infections with Enterobacteriaceae was conducted between 1 | 6 | 2019-1 | 6 | 2020 at the University Children's Hospital in Damascus.

Results: The research sample included 277 of which 125 samples were resistant to carbapenem, the most common specie was klebsiella then E.coli, these bacteria demonstrated high resistance rates to almost all antibiotics, and this was clear with E.coli group.

Conclusion: our treatment options are very limited and colistin is the empirical antibiotic, that is why it is necessary to include the newer antibiotics in treatment plans.