Comparison of Vitamin D Levels In Late Neonatal Hypocalcaemia Cases And Their Mothers with A Control Group

Abstract

Introduction: Maternal vitamin D (VD) status is the dominant determinant of the newborn's VD status, that may plays a role in the setting of late-onset neonatal hypocalcemia (LNH).This study aims to study the VD status in LNH cases and verify if maternal and infant VD levels are correlated and to compare it with the VD status in a normal control group.

Methods: An observational prospective study with control group study, it included the LNH newborn and mothers and a normal control group newborn and mothers, VD was studied in the newborn and mothers and compared in the two groups, the study was made in the university children hospital of Damascus.

Results: the study included 41 LNH cases and their mothers and 20 normal newborn and their mother, the mean 25OHVitD level was 10.6(±4.53) ng/ml in the LNH and 10.26 (±4.97) in their mothers, while the mean level were 27.9 (±3.73) and 23.92 (±4.45) ng/ml in the normal newborn and their mothers respectively; The newborn VD status correlate with that of their mothers (P<0.05). In the LNH group 95% of VD levels of the newborn and 100% of their mothers levels were deficient(< 20 ng/ml), while 70% of VD levels of the newborn and 75% of their mothers levels were insufficient(< 30 ng/ml )in the control group with significant difference(P<0.05).

Conclusion: VD deficiency contributes to LNH and correlate with the VD deficiency in the pregnant woman. This fact should be considered in the general health policy.