A study of prognostic factors of pediatric Osteosarcoma in Children's University Hospital in Damascus

Abstract

Abstract

BACKGROUND 

Outcomes in pediatric osteosarcoma have dramatically improved over the past few decades, with overall survival rates of 70% and 30% for patients with localized and metastatic disease, respectively.

PURPOSE

We aimed to review outcome and prognostic factors that influence overall survival (OS) in osteosarcoma patients at Childrens' University Hospital in Damascus.

PATIENTS AND METHODS

We retrospectively reviewed clinical characteristics and outcomes of 28 patients treated between 2005 and 2015 at a single institution in Syria. All patients received a uniform chemotherapy regimen consisting of ifosphamide, etoposide, Cisplatin and doxorubicin depending on their tumor stage.

RESULTS

After a follow-up of 60 months, patients with osteosarcoma had 5- year overall and event-free survival rates of approximately 57.1 % and 46.4%, respectively. The most common primary site was the long bones around the knee (n = 25; 89.2%). 8 patients (28.5%) had metastatic disease to lungs, and t 1 (3.5%) had synchronous multifocal bone disease. In our analysis, adverse prognostic factors were metastases at diagnosis, elevated concentrations of ALP and relapsed disease .

CONCLUSION

Metastatic disease at diagnosis , elevated concentrations of ALP and relapse have been established as the most powerful prognostic parameters in our analysis.

Keywords:  Osteosarcoma; children; prognosis.