The Effect of Valsartan on Cisplatin Nephrotoxicity

Abstract

Cisplatin-induced nephrotoxicity is a serious complication of cisplatin chemotherapy, with cisplatin being one of the most commonly used chemotherapy agents in the treatment of solid tumors.

This study aims to investigate the protective effect of valsartan on cisplatin-induced nephrotoxicity in rats.

20 male Albino Wistar rats were divided in 3 groups (6-7 animals/group): (C) Controls, (P) cisplatin (2.5 mg/kg for 5 days), (V) cisplatin + Valsartan (3 mg/kg 7 days). Blood urea and serum creatinine levels were measured to assess renal function, kidney/body weight ratio was calculated, and histological changes were evaluated. The statistical study was conducted using Prism. Parametric data was evaluated using the ANOVA test, followed by Uncorrected Fisher's LSD test. The non-parametric data were evaluated by Mann-Whitney and Fisher tests. The results were considered significant at P<0.05.

A significant increase was observed in urea and creatinine levels, and in the total/body weight ratio in group (P) compared to group C. Histological examination showed significant tubular and glomerular injuries. A significant improvement was observed in the prevention groups of valsartan (V).

In conclusion, valsartan showed the ability to protect the kidney from cisplatin-induced nephrotoxicity in varying proportions.