Rapid and clean synthesis of some Mannich base derivatives by Reacting of N-Hydroxymethyl -phthalimide with different Aminopyridines and Evaluation their Biological Activity

Abstract

This study includes a synthesis of two of Mannich bases, these compounds are:

N-[(2-pyridyl) aminomethyl] phthalimide, N-[(4-Methyl-2-pyridyl)- aminomethyl] phthalimide derived from reaction of N-hydroxymethyl- phthalimide with different aminopyridines, by using a simple, rapid and clean method. The products then were compared with the ones prepared by conventional method (refluxing in solvent) .The prepared compounds were characterized by FT-IR  and  LC-MS spectra. All compounds were also evaluated for their biological activity in vitro against Gram-positive bacteria Staphylococcus Epidermidis and fungi Candida albicans.