Potentiometric determination of Bisoprolol fumarat (BPF) by Carbon Paste Electrode (CPE)

Abstract

A new Carbon Paste Electrode (CPE) for Bisoprolol fumarat (BPF) modified with complex of Bisoprolol fumarat (BPF) with Sodium tetraphenylborate (NaTPB) as electroactive material was prepared. The best performances were obtained by carbon paste electrode with the composition graphite powder (47.5%), DOP as plasticizer (47.5%) and BPF-NaTPB as electro active material (5%). This electrode exhibited a linear potential response to Bisoprololl fumarat in the concentration range (1.11×10^-6-2.08×10^-3)M with Nernstian slope of 29.073mV/decade and detection limit of 9.58×10^-7M. It is suitable for Bisoprolol fumarat determination within pH (3.74-8.51), and performs well about 84 days. This electrode is selective for Bisoprolol fumarat over a large number of metal ions and Excipient that expected exist in medical sample. Described carbon paste electrode can be used in analytical measurement by direct potentiometry for determination of Bisoprolol fumarat  in experimental and drug samples.