Synthesis of new derivatives containing side chains associated with basic nucleus of piperidin-4-one and studying the structure with antioxidant activity

Abstract

This search aims to synthesis  new piperidone derivatives  that have important biological activity. These compounds are the following: 1-ethyl (2-hydroxy)-3a-methyl-3e-hydroxy-6e-(2-benzyloxy  benzaldehyde) piperidin-4-one(II), and its oxime derivative was 1-ethyl (2-hydroxy)-3a-methyl-3e-hydroxy-6e-(2-benzyloxy benzaldehyde) piperidone oxime-4(III). Synthetic methods of these compounds were described and identified their properties and physical constants. these synthesized compounds were characterized by infrared spectra (IR), and Proton nuclear magnetic resonance (¹H-NMR), and Their  antioxidant activity were tested by DPPH^. assay. So, the percentage of free radicals inhibition was calculated for synthesized compounds and its results were compared with Standard Series of Ascorbic acid. The results indicated that the value of  for piperidone oxime-4 derivative(III) equal to 31.44 mg/ml, whereas its value 61.50mg/ml for piperidin-4-one derivative(II), so piperidone oxime-4 derivative(III) has higher ability of free radicals scavenging.