Study of changes in some physiological and biochemical parameters in patients with benign prostatic hyperplasia

Abstract

Benign prostatic hyperplasia (BPH) is one of the most common diseases

among men and causes many side effects in the lower urinary tract (LUTS). Some of these symptoms can be painful, making life difficult for people with BPH. These symptoms may develop into bigger problems if not treated early, such as urinary tract infections that develop further to cause urinary tract cancers. Many data support the existence of a link between hormonal changes and the occurrence of benign prostatic hyperplasia, so in this article we discussed a number of hormonal and biochemical criteria that many literatures claim are indicators of the occurrence of benign prostatic hyperplasia (BPH), namely the concentration of testosterone (T), dihydrotestosterone (DHT), prostate-specific antigen (PSA), and alpha-5 enzyme (α-5), and whether these criteria are useful in the early detection of prostate enlargement by comparing the concentrations of these criteria between a control group and a group with BPH. Therefore, our article aimed to link changes in the concentrations of these criteria to the occurrence of BPH and to use these criteria as a qualitative indicator of the occurrence of BPH, by measuring the concentrations of these criteria for individuals in each group separately and then studying the differences in the concentrations of these criteria between the two groups and the extent of their association in the occurrence of benign prostatic hyperplasia, using specific statistical tests, the most important of which are the ANOVA test, Pearson's R correlation coefficient, and the ROC test. The concentrations of the criteria of the individuals of both groups were measured using a special ELISA kit for each criterion separately, and then these results were studied statistically to achieve the aim of the study. These results showed that there were significant differences between the concentrations of the criteria of the individuals of the control group and the individuals of the BPH group, and there was a close relationship between the occurrence of BPH and the studied criteria, and the ROC curve was drawn showing the true positive values ​​and false positive values. These results were discussed and it became clear that these indicators can be used as tools to predict the occurrence of benign prostatic hyperplasia..