Conjugation of Riboflavin to TPAs Ligands with two halogens atoms in -- position substitution

Abstract

In a previous study, the complexes of the ligands TPAs [tris(pyridin-2-ylmethyl)amine] and TPAs with -a- position substitution by halogens (tetradents) have shown very important properties in the process of oxygen activation and transfer to substrate. On the other hand, we have been able to conjugate riboflavin, which plays the role of electron-mediator in biological oxidation processes with a trident ligand; the DPAs, this allowed us to obtain reductive activation of dioxygen molecule. In this paper, we aim to bind the riboflavin molecule to a set of TPAs ligands with two -a-position substitutions by halogens and a third one by cyano-group. After the reduction of cyano-group to primary amin, which allowed the binding to riboflavin under special reactional conditions, we have obtained ligands to form a reductive activation center capable of dioxygen activation.