Chemical and analytical synthesis of some carbazole derivatives of Mannish bases and evaluation of their biological and antioxidant activity

Abstract

Several carbazole derivatives were prepared through Mannich reaction starting from the reaction of carbazole with formaldehyde to give hydroxy methyl carbazole (I), which reacts with primary amines  such:( 4-aminoquinidine , 2-amino-4,6-dimethoxypyrimidine , 2-amino-5-nitrophenol ,4-amino-benzaldehyde and 2-amino-4-picolin) by two methods (oil heat method and reflux distillation method), to give new organic chemical compounds from Manish bases and to compare the yield of the products with both methods. The prepared derivatives were described using spectroscopic techniques (FTIR, ¹HNMR, LC-MS). The effect of some prepared compounds on four bacterial strains was studied: two of them are gram-positive (staphylococcus albicans, streptococcus arius) and two are gram-negative (pseudomonas aeruginosa, escherichia coil)،  the results were compared with

the antibiotic (Ceftriaxone), the results showed good effectiveness of compound (III) through reaction carbazole with formaldehyde with 2-amino 4.6-dimethoxypyrimidine  at a concentration of 1000 ppm.

The antioxidant activity of the prepared compounds was evaluated using the DPPH method, as these compounds showed an antioxidant capacity of compound (III) of up to 75.09% at a concentration of 1250 µg/ml and gave an IC₅₀ value = 282.7 µg/ml compared with the control ascorbic acid, which had a percentage of The percentage of antioxidants was 94.41% and gave an IC50 value = 204.1 µg/ml.